□□ ―124―PI3-kinase□□□□□□□□□□□□□□□□□□□□□□□ Circuit-specific mechanism underlying emotional perception □□□□□□□□□□□□□□□□□□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□[1] Hideaki T. Matsubayashi*, Jack Mountain, Nozomi Takahashi, Abhijit Deb Roy, Tony □□□□□Yao, Amy F. Peterson, Cristian Saez Gonzalez, Ibuki Kawamata, Takanari Inoue*, Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP-2-mediated endocytosis, Nature Communicatoins, in press. □□Sai Sun (Creative Interdisciplinary Research Division/Cognitive Neuroscience) The ability to understand and interpret subtle emotions conveyed through facial expressions is crucial for effective social interaction. Yet, individuals with neuropsychiatric disorders often face difficulties in social perception and cognition. My research seeks to gain a comprehensive understanding of the information transmission pathways of the frontal-amygdala circuit underlying emotion recognition, using a variety of techniques such as EEG and fMRI combined with psychological experiments and computational modeling. Our findings have revealed the directional connectivity between the amygdala, dmPFC, and vmPFC, as well as the altered behavioral responses and dysfunctions in the frontal-amygdala network in individuals with psychiatric disorders. These findings are valuable in guiding clinical translation studies with the aim to improve social abilities through targeted neuromodulation of specific circuits in individuals with neuropsychiatric disorders.□References: Sun et al., Scientific Data 2023; Translational Psychiatry 2023; Neuroimage 2023. Yu, Lin, Sun et al., Annals of the New York Academy of Sciences. Zhang, Sun et al., Scientific Reports. □
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