―138―□□□ □□□□□□□□□□□□□□□□□□□□□ Aseel Marahleh (Creative Interdisciplinary Research Division/Advanced Basic Research) In our project we utilized a systems biology approach to studying the effects of hyperglycemia on the skeleton. We present transcriptomic and epitranscriptomic data. Our data reveal that high glucose diversifies the transcriptome by regulating RNA transcripts' splicing program and RNA modifications and highlight a number of significantly enriched RBP motifs with a potential role in regulating the AS landscape in hyperglycemic bones. References [1] The osteocyte and its osteoclastogenic potential., Marahleh A, et al, Fron Endo, 1121727-1121727. [2] Hyperglycemia Induces Extensive Alternative Splicing Changes In Osteocyte Enriched Cultures With Minimal Transcriptional Alterations., Marahleh A, et al, ASBMR 2023 Annual Meeting. [3] High Glucose Induces Alternative Splicing Changes in Primary Osteocytes With Minimal Transcriptional Alterations., Marahleh A, et al, Cell Bio 2023. Boston, MA, USA. [4] Marahleh A, et al, The 46th Annual Meeting of the MBSJ. □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□(□□□)□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□CO2□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ (□□) □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ (□□□) □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□1 □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□2 □□□□□[1] Tahara, A.; CSD Communications 2023, CCDC 192055 (doi: 10.5517/ccdc.csd.cc21v7ms) / CCDC 192056 (doi: 10.5517/ccdc.csd.cc21v7nt) / CCDC 2322689 (doi: 10.5517/ccdc.csd.cc2hyygw). [2] NEDO □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□ (□□□□). Mapping osteocyte multiomics in response to hyperglycemia □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□
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