Frontier Research Institute for Interdisciplinary Sciences
Tohoku University

This study aims to construct artificial cytoskeletons as new tools for cell manipulation. The cytoskeleton functions as the framework of the cell, and manipulating it can induce changes in cell shape, as well as the transport and destruction of internal structures, making it a promising avenue for novel disease treatments. For example, disrupting structures within nerve cells could lead to the development of therapies that slow the progression of neurodegenerative diseases. However, traditional methods have targeted endogenous cytoskeletons, which interferes with the cell's natural functions. Therefore, this study aims to address these issues by designing new artificial cytoskeletons through the exploration of non-mammalian genomes and the use of structural analysis and machine learning techniques. This approach is expected to develop new tools that control specific structures and functions while maintaining cellular functionality. Additionally, since polymerizing proteins like the cytoskeleton have potential applications as nanomaterials, this research aims to advance fields such as materials science and medicine. Through this study, we seek to promote interdisciplinary collaboration and strengthen the foundation for cross-disciplinary research.