Frontier Research Institute for Interdisciplinary Sciences
Tohoku University

Advancements in understanding brain pathophysiology, coupled with the ability to generate controlled electric, magnetic, or acoustic fields, have propelled neuromodulation to the forefront of therapeutic strategies for neurological and psychiatric disorders. Among these modalities, magnetic stimulation offers unique advantages for non-invasive brain modulation. However, conventional approaches such as transcranial magnetic stimulation (TMS) remain bulky and are limited in spatial resolution and targeting precision.

To overcome these limitations, this project focuses on developing miniature magnetic μCoil fibers capable of stimulating both brain and peripheral neural activity with high spatial precision. Leveraging a rotational thermal drawing technique, which has been originally established in our group (S. Kato, Y. Guo*, Microsystems & Nanoengineering 10.1 (2024):14), we fabricate flexible, microscale multimaterial fibers that incorporate magnetic microcoils within a single strand. These fibers uniquely combine miniature dimensions and mechanical flexibility while enabling spatially confined magnetic field stimulation, a capability unattainable with conventional technologies.

This innovation is expected to facilitate selective modulation of deep brain and peripheral neural circuits, contributing to the elucidation of disease mechanisms and the development of novel diagnostic and therapeutic strategies. Furthermore, the platform holds promise for future applications in wearable and implantable medical devices, positioning it as a foundational technology for next-generation neuromodulation.