Frontier Research Institute for Interdisciplinary Sciences
Tohoku University


Tenure in FRIS 2018.3-2022.3

Yuji Nashimoto

Assistant ProfessorLife and Environments

Mentor Information
Hitoshi Shiku (Department of Applied Chemistry)
Research Fields Biomedical engineering, Electrochemistry, Microengineering
Research Subjects
  • Development of engineering tools for the construction and the evaluation of three dimensional tissue models using scanning probe microscopy techniques
Academic Society Membership The Chemical Society of Japan, The Japan Society for Analytical Chemistry, Society for Chemistry and Micro-Nano Systems, The Institutes of Electrical Engineers of Japan, Biomedical Engineering Society
Research Outline  

My research interest is development of micro/nanoengineering tools, especially scanning probes, to engineer organ-mimic models and to evaluate their functions in vitro. Recent culture techniques allow us to generate a number of mini-organ models, such as vasculature, brain, liver and kidney, etc.: however, techniques to regulate their morphology at microscale and to analyze their functions in situ have not been fully addressed.

Scanning probe microscopy (SPM) provides multiple information such as topography, the distribution chemical substances at micro/nanometer scale, which are difficult to get in a normal optical microscopy. In addition, there is also another aspect to SPMs. By virtue of their spatial resolution, these SPMs techniques enable the precise synthesis, interrogation, and perturbation of tissue microenvironments. Utilizing SPM techniques, I’m investigating the role of the tissue microenvironment. Specifically, I’m focusing on scanning electrochemical microscopy (SECM) and scanning ion conductance microscopy (SICM). I seek to translate our findings into medical and biotechnology fields.


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