Frontier Research Institute for Interdisciplinary Sciences
Tohoku University

Researcher

Nozomi Saito

Past information from November 2012 to March 2016

Nozomi Saito

Assistant Professoranced Basic Science

Mentor Information
Professor
Masahiko Yamaguchi (Graduate School of Pharmaceutical Sciences)
Research Fields Organic Chemistry
Research Subjects
  • Interdisciplinary Study on Helical Functional Materials Based on Organic Synthetic Chemistry
Academic Society Membership The Chemical Society of Japan / The Society of Synthetic Organic Chemistry, Japan / The Pharmaceutical Society of Japan
Research Outline  

Helix is an important structure of materials at the molecular-level and bulk-level, as exemplified by DNA and plant vines. Development of functions of helix-materials has great potentials to solve social issues in various fields, such as creation of medicines and development of functional materials. Properties of helix-materials, however, have not been well known, because of the lack of preparation method. The aim of my research is to explore the properties of helical substances and to develop helix-based functional materials by interdisciplinary approach, which is based on synthetic organic chemistry.

1,12-Dimethylbenzo[c]phenanthrene, a helical molecule called “helicene”, is used in this work. This molecule has a helically twisted -plane containing fused four benzene rings, which can possess mirror-imaged right- and left-handed chiral structures. Two subjects are underway using the helicene: (1) To develop functional helicene molecules and to investigate the interactions with biological molecules and organs. (2) To develop bulk materials using helical oligomers containing the helicenes, which exhibit muscle-like motional function based on the spring-like molecular structural change between double helices and random coils. In order to integrate the molecular-level motion to the macroscopic motion and to realize a large contraction-extension motion like a muscle, methods to construct ordered, anisotropic, and flexible self-assembled systems are investigated.

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